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15th BOSTON A-FIB SYMPOSIUM, January 14-16, 2010 "Atrial Fibrillation: Mechanisms and
08-05-2010, 12:50 PM (Acest mesaj a fost modificat ultima dată: 08-05-2010 12:52 PM de razvi.)
Mesaj: #1
15th BOSTON A-FIB SYMPOSIUM, January 14-16, 2010 "Atrial Fibrillation: Mechanisms and
15th BOSTON A-FIB SYMPOSIUM, January 14-16, 2010 "Atrial Fibrillation: Mechanisms and New Directions in Therapy"

The annual international Boston A-Fib Symposium is one of the most important conferences on A-Fib in the world. It brings together researchers and doctors who share the latest information. However, if you haven't read and understood most of A-Fib.com, it may be difficult reading.

OVERVIEW-HIGHLIGHTS

The overall mood of the 15th annual Boston A-Fib Symposium seemed to be a sense or feeling of certainty in making progress and moving forward.
One might describe this Symposium's signature or most prominent topic of interest as "New Achievements in A-Fib Imaging/Mapping."

4D & 5D IMAGING/MAPPING IN A-FIB
In a thought provoking and somewhat controversial presentation, Dr. Douglas Packer described new developments in A-Fib Imaging/Mapping as "4D and 5D Imaging."
Over the last few years, A-Fib doctors and medical companies have developed very sophisticated Imaging/Mapping systems for doing A-Fib ablations. For example, in the Satellite Case Transmission presented by Massachusetts General, Dr. Moussa Mansour watched on a monitor a 3D rotating, detailed color cartoon image of the patient's heart. He then pushed a button to open up the end of the heart and look inside.
Rotational Angiography produces even more astounding images. Instead of cartoon recreations, it shows the patient's actual heart in a 3D, real time rotation. One can see the heart in every detail and can watch where the ablation catheter is in the heart. (Seeing this for the first time takes one's breath away.)
(The author is negotiating with different Imaging/Mapping companies to make their images of the heart available on A-Fib.com.)
Time is the 4th A-Fib Dimension, according to Dr. Packer. An example is the CardioFocus Endoscopic laser balloon Ablation System. The doctor operating the CardioFocus catheter can directly see in color 3D real time where the CardioFocus laser balloon is positioned in the heart. The operator also sees tissue change imaging (A-Fib 4D), how the heart tissue is affected over time as the Near Red Laser Light ablates in overlapping arcs around the Pulmonary Vein opening. (This system is not yet approved by the FDA for use in the US.)
The 5th A-Fib dimension would include other parameters such as integrated temperature sensing imaging probes (and contact force imaging---how much pressure an ablation catheter applies when ablating heart tissue).

ATHLETES AND A-FIB
Athletes and endurance training was the subject of two sessions and a great deal of discussion. Dr. Stanley Nattel presented studies indicating that high level physical training doubled the risk of developing A-Fib. In Dr. Nattel's animal lab experiments, high level exercise training (30+ miles/week) developed A-Fib by two mechanisms:
1. increasing Vagal tone,
2. producing structural remodeling of the heart---atrial overload leads to atrial enlargement, increases atrial fibrosis and ventricular hypertrophy.
Dr. Riccardo Cappato described how A-Fib hurts athletes' performance and their ability to exercise. It also makes them ineligible for competitions because they fail pre-qualifying tests (other professions and avocations such as pilots have this same problem).
Because athletes often can not tolerate antiarrhythmic drugs and/or refuse to take them, Dr. Cappato and other doctors in a panel discussion say they recommend Pulmonary Vein Ablation as first line treatment for athletes. A successful PV ablation restores athletes to full competition intensity and makes them re-eligible to compete.
Current guidelines state "catheter ablation of A-Fib in general should not be considered as first line therapy." At least one antiarrhythmic med should be tried first. But the guidelines also state, "in rare clinical situations, it may be appropriate to perform catheter ablation of AF as first line therapy." Dr. Eric Prystowsky, who was instrumental in writing the current A-Fib guidelines, stated that he uses PV Ablation as first line therapy for athletes because of the above reasons.

ABLATION NOT A PERMANENT "CURE" FOR A-FIB
When counseling patients with A-Fib, a successful A-Fib ablation is considered the only current hope of a permanent "cure" for A-Fib (as compared to, for example, Rhythm or Rate control drugs which tend to lose their effectiveness over time). But a study by Dr. Francis Marchlinski cast doubt on this hypothesis.
He persuaded patients who had experienced successful PV ablations and who were A-Fib symptom free, to be re-examined in the EP lab. He found that some had Regrowth/Reconnection in their ablated vein openings even though they were A-Fib symptom free. He also examined patients who had Regrowth/Reconnection and reoccurrence of A-Fib after a successful PV ablation.
He estimated that there is a 5-6% chance of Regrowth/Reconnection each year, out to five years. He doesn't have data for beyond five years.
(The author has been A-Fib symptom free for 12 years. Doctors he spoke to didn't think there was much chance of A-Fib reoccurrence after 12 years.
However, the author will eliminate the work "cure" from all A-Fib.com postings and instead use the term "A-Fib symptom free.")

CONTACT FORCE SENSING
A Mini-Symposium was devoted to the subject of Contact Force Sensing.
When performing an ablation, doctors monitor power, duration, and temperature; but not how hard the ablation catheter presses on heart tissue. Insufficient ablation catheter contact can produce lesions that don't work or that do not penetrate heart tissue, while too much contact or pressure can cause perforation or damage to adjacent structures like the esophagus.
Dr. Karl-Heinz Kuck described a study using the TactiCath contact force sensing system which found a high variability of force applied both between different operators (which one would expect), and during an ablation by one operator. 12% of ablation burns had a low force contact of under five grams. (Perhaps this is one of the causes of re-occurrence of A-Fib after ablation.) 82% of patients had a force of over 100 grams applied at least once during their ablation. This could potentially cause steam pop, puncture, and clotting. Dr. Hiroshi Nakagawa explained how Contact Force Sensing catheters would eliminate the above problems.
Dr. Dipen Shah presented studies which showed that Contact Force Sensing:
1. Improves lesion effectiveness
2. Reduces ineffective applications (by indicating insufficient contact force)
3. Reduces collateral damage
4. Improves safety
5. Predicts sites of conduction recovery

STROKE PREVENTION
A Mini Symposium was held on Stroke Prevention in A-Fib.
Dr. David Singer described why A-Fib is a major risk factor for stroke. Because in A-FIb the left atrium doesn't contract to push blood into the ventricle, clots can easily form especially in the Left Atrial Appendage.
Warfarin (Coumadin) reduces the risk of stroke by 68% and is safe at the proper levels. Warfarin's risk of producing an hemorrhagic stroke is only 0.3%/year compared to a normal risk of 0.1%/year. But warfarin is underused. 40% of people who should be on warfarin don't take it, perhaps because of its side effects, bleeding risk, and the difficulty in maintaining proper INR levels.
Aspirin is much less effective, only reducing the risk of stroke by approximately 21%. Clopidogrel, when taken with aspirin, reduces the risk of stroke by approximately 28%. But it significantly increases the risk of major hemorrhage, mostly gastrointestinal.
The good news, both for patients and doctors, is stroke rates in A-Fib are declining.

DABIGATRON TO REPLACE WARFARIN?
The RE-LY study found that dabigatron reduces the risk of stroke by 30% while also reducing the risk of intracranial bleeding by 30% (dabigatron dose 150 mg). It also reduces vascular death. Unlike warfarin which needs four days loading to be effective, dabigatron works right away. It doesn't have to be monitored for INR levels. (Both doctors and patients are impatiently waiting for FDA approval for dabigatron, which hopefully will come soon.)

THE WATCHMAN DEVICE TO PREVENT STROKE
The Watchman Device works by closing off the Left Atrial Appendage where 90% of clots/strokes come from. (See The Watchman Device.)
Dr. Zoltan Turi showed a slide of a man who had a Watchman Device installed, but died nine months later from other causes. His family graciously allowed doctors to do an autopsy to examine how the Watchman device had worked. The Watchman Device was covered over by smooth heart muscle tissue which looked like any other part of the heart. (The Editor is negotiating to get a copy of this slide for A-Fib.com.)
Data from the Watchman Device study showed that it is safe, effective and easily installed (one doctor said he installed them in 20 minutes). A surgeon speaking at the Symposium said he had to remove Watchman Devices (implying that this is a major problem with the Watchman Device). Acknowledging there was a short learning curve when first installing the Watchman Device, Dr. Turi said that to date only four have had to be removed.
An FDA preliminary panel has approved the Watchman Device. But the vote was close---7-5. All agreed that the Watchman Device worked, but some wanted to see more than 800 cases. Clinical trials of the Watchman Device have been extended.

FDA AT THE BOSTON A-FIB SYMPOSIUM
Dr. Randall Brockman and Dr. Jun Dong from the FDA both expressed the FDA's willingness to help and encourage the development of effective therapies for A-Fib. Dr. Brockman pointed out that A-Fib is a major public health issue (some have called it an epidemic). He also expressed the FDA's interest in developing an A-Fib Registry (SAFARI). (He was asked why new devices or drugs seem to be always started in Europe.)
Dr. Dong explained the FDA's Investigational Device Exemption (IDE) and how it could be used by both industry and physicians. He welcomed physician-initiated trials and gave the audience his email address and office phone number.

MEASURING QUALITY OF LIFE IN A-FIB
Having A-Fib can be devastating. A-Fib can affect General and Mental Health, as well as Physical and Social Function.
Some A-Fib symptoms can be described and objectively quantified by degree and severity: Palpitations, Dyspnea (difficulty breathing), Chest Pressure and Pain, Dizziness, Presyncope, Syncope (fainting), Exercise Intolerance and Fatigue. Other symptoms are more subjective: such as Anxiety and Depression.
"Quality of Life" is a subjective phenomenon based on each person's perception, experience, beliefs, and expectations. What may be intolerable for one person may not be all that bad for another. Dr. Jeremy Ruskin is proposing an A-Fib Symptom Classification System that also includes Quality of Life. Such a system or universally accepted shorthand would facilitate communication between doctors and patients, and between health care providers.
CLASS SYMPTOM SEVERITY
I. Asymptomatic
II. Mild---having a mild affect on a patient's qualify of life, mild awareness
of symptoms in Persistent/Permanent A-Fib, rare episodes (less than a
few a year) in Paroxysmal A-Fib
III. Moderate---having a moderate affect on quality of life, moderate
awareness of symptoms on most days in Persistent/Permanent A-Fib,
more common episodes (more than every few months) and/or more
severe symptoms in Paroxysmal A-Fib.
IV. Severe---having a severe effect on quality of life, very unpleasant
symptoms in Persistent/Permanent A-Fib, frequent and highly
symptomatic episodes in Paroxysmal A-Fib
Syncope (fainting)
Congestive Heart Failure because of A-Fib

DR. JEREMY RUSKIN HONORED
Dr. Jeremy Ruskin from Massachusetts General Hospital was honored for his 15 years of organizing the Boston A-Fib Symposium. He was given a Chelsea clock from Boston and was enthusiastically applauded for his years of service to the A-Fib community.

Pentru o traducere, dar nu prea exacta :

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08-05-2010, 06:32 PM
Mesaj: #2
RE: 15th BOSTON A-FIB SYMPOSIUM, January 14-16, 2010 "Atrial Fibrillation: Mechanisms and
Multumesc, Razvi, m-am descurcat. Iar m-apuca furiile si disperarea: astia dezvolta deja sisteme de 4, respectiv 5D, iar noi cu amaritul si UNICUL nostru 3D putem sa crapam veseli de FA-uri. Mi se pare o samavolnicie absolut criminala sistarea interventiilor, oricare ar fi motivele!!!! Zic ca asta nicaieri in lume - evident, in afara de Romanica - nu s-ar putea intimpla!!!
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11-09-2014, 03:55 PM
Mesaj: #3
RE: 15th BOSTON A-FIB SYMPOSIUM, January 14-16, 2010 "Atrial Fibrillation: Mechanisms and
Buna, am varsta de 65 de ani, insa de la 60 de ani am inceput sa am dureri in piept, respiratie dificila, ameteam si oboseam foarte repede. In plus de simptomatologia aceasta aveam si un AVC hemoragic facut pe la varsta de 58 de ani. Am inceput de la capul locului investiigatiile: EKG, ecografii cardiace, ecografii transesofagiene. Doctorii au concluzionat ca ne confruntam cu FA. Din cauza AVC ului suferit nu mi puteau administra tratament cu anticoagulante si totul a ramas in aer. Fiind foarte speriata de starea sanatatii mele am inceput sa ma interesez de variante inafara, crezand in doctori. Intr un final am ajuns in Germania la o clinica de cardiologie. Aici am reluat toate investigatiile, inclusiv cele neurologice. Doctorii mi au explicat riscurile la care ma expun daca incep tratamentul anticoagulant, care de altfel sunt foarte mari, motiv pentru care dansii mi au propus ceva total nou pentru mine. Auzisem foarte vag de medicina interventionala si ce face ea, insa aici tot sistemul lor era dezvoltat pe asta! Mi au propus Watchman, nu stiam ce inseamna si cum decurg etapele pentru acest dispozitiv. Mi s a explicat exact ce face el si de ce am nevoie de el. Initial mi s a parut ca e prea mult fata de ce stiam eu si aveam in mine o doza de reticenta…era foarte complicat…dizpozitivul asta inchide urechiusa stanga care la noi se face prin chirurgie clasica, adica operatie pe cord deschis. In plus eu ajunsesem acolo cu diagnostic de fibrilatie atriala, ce treaba avea asta? Eram contrariata.. in loc sa ma lamuresc, eram mai bagata in ceata. A venit doctorita la mine si a inceput sa imi explice ce face Watchman si de ce am nevoie de el, ca e sansa mea cea mare. Am intrat in interventie urmatoarea zi, iar finalul fericit a fost ca la o luna si jumatate dupa implantare am putut sa nu mai iau deloc anticoagulante, adica sa nu imi mai pun viata in pericol. Multumesc acestor doctori care au gasit o solutie si in cazul meu,care e unul mai dificil. Cand am ajuns In tara si am povestit experienta prietenilor mei, erau uimiti de evolutia nemti si oarecum indignati pe sistemul sanitar si spitalicesc romanesc. Cu toate acestea nu dupa foarte mult timp m am bucurat sa aud ca acest Watchman se poate implanta si la noi in tara. Eu ma simt foarte bine cu el si sunt constienta de cate riscuri am reusit sa elimin prin existenta acestui dispozitiv in organismul meu. Il recomand celor carora le este contraindicat tratamentul cu anticoagulant pentru ca ajuta mult. O zi buna si sanatate.
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11-09-2014, 05:17 PM
Mesaj: #4
RE: 15th BOSTON A-FIB SYMPOSIUM, January 14-16, 2010 "Atrial Fibrillation: Mechanisms and
Îi potolește cineva pe "boții" ăștia?
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12-09-2014, 11:49 AM
Mesaj: #5
RE: 15th BOSTON A-FIB SYMPOSIUM, January 14-16, 2010 "Atrial Fibrillation: Mechanisms and
Acest dispozitiv, caruia ii faci reclama, "rezolva" doar partial problema, riscul de embolie ramanand in continuare.
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24-09-2014, 08:02 PM (Acest mesaj a fost modificat ultima dată: 24-09-2014 08:08 PM de CristianG.)
Mesaj: #6
RE: 15th BOSTON A-FIB SYMPOSIUM, January 14-16, 2010 "Atrial Fibrillation: Mechanisms and
Cand vezi tot felul de prostii, gen "dispozitiv Watchman", cu reclama ticaloasa aferenta, parca iti vine sa le spui, iti doresc episodul meu de fibrilatie de alaltaieri noapte. Am avut parte de tot felul de posibile tratamente, de la gandire pozitiva pana la ceaiuri din nu stiu ce radacini de plante rare dintr-un anume colt din India, incarcate energetic pozitiv. Vezi Doamne, eu nu am vrut sa le urmez, din acest motiv am inca problema asta. Nu gandesc pozitiv. Uaaah...
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24-09-2014, 08:28 PM
Mesaj: #7
RE: 15th BOSTON A-FIB SYMPOSIUM, January 14-16, 2010 "Atrial Fibrillation: Mechanisms and
Ce-ai mai făcut cu apneea?
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25-09-2014, 07:17 PM
Mesaj: #8
RE: 15th BOSTON A-FIB SYMPOSIUM, January 14-16, 2010 "Atrial Fibrillation: Mechanisms and
Am fost la medical ORL, nu mi-a operat cornetele nazale, in schimb mi-a dat tratament (Nasonex spay + aerius pastile). Am deja o luna si parca respir mai bine noaptea. Nu perfect dar mai bine, ma trezesc mai odihnit. Nu mi se mai infunda asa des nasul, ziua am momente cand respir perfect pe ambele nari. Nu stiu daca are legatura dar episoadele de fibrilatie mi s-au mai rarit. Spre exemplu in iulie am facut toata luna, din 2 in 2 zile. De pe 1 pana pe 6 august am facut in fiecare noapte. De pe 1 august am inceput sa iau regulat cantitati mai mari de potasiu si magneziu (500mg K si 300mg Mg, impartite in mai multe reprize pe durata zilei). De pe 6 aug au inceput sa imi scada semnificativ extasistolele, in prezent extra-uri nu mai am ziua aproape deloc, foarte putine perceptibile. Crizele de fibrilatie s-au rarit, ultimele 2 au fost la interval de 10, respectiv 12 zile. Am inceput sa mai sper, mai ales ca ziua sunt un om normal. Faceam extra-uri de dimineata pana seara, fara oprire. Acum nu mai am asa ceva si ma rog in fiecare zi sa nu se intoarca starea aia. Spre exemplu mi s-a intamplat intr-o dimineata sa ma trezesc si sa imi dau seama ca sunt culcat pe partea stanga, lucru pe care nu l-am mai facut de aproape 1 an si culmea.... fara extra-uri si fara fibrilatie. Daca as fi facut asta intr-o noapte din luna iulie spre exemplu, eram instantaneu in fibrilatie. Dormeam pe o canapea, tocmai sa nu pot sa ma intorc in somn pe partea stanga. Om vedea ce va mai fi, dar faptul ca am zile la rand absolut normale in da sperante ca macar o sa mai raresc crizele. De vindecare, ... cam greu dupa atatea episoade, dar macar sa o tin sub control, sa am crize cat mai rare.
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25-09-2014, 09:31 PM (Acest mesaj a fost modificat ultima dată: 25-09-2014 09:34 PM de ursamajor.)
Mesaj: #9
RE: 15th BOSTON A-FIB SYMPOSIUM, January 14-16, 2010 "Atrial Fibrillation: Mechanisms and
Ascultă, am mai spus-o, apneea nu se face din cauza nasului. sigh Obstrucția e undeva mai jos, pe căile respiratorii adânci. Pe bune, investigheaz-o și trateaz-o. Legătura dintre ea și FiA este clară. E posibil chiar să nu mai faci FiA dacă tratezi CORECT apneea.
Mie mi se înfundă nasul cvasipermanent, dar din fericire, după ce înainte de culcare prizez Bixtonim, noaptea stă mai mult desfundat. Însă dorm cu CPAP-ul și cu masca pe față permanent. Și de frica recidivelor dar și fiindcă nici nu mai pot dormi fără el. Mă trezesc odihnit și cu chef de viață, după anii de clavar din trecutul apropiat. Primul lucru pe care l-a întrebat doctorul la controlul de 3 luni a fost: "dormi cu pompa?" De ce? Fiindcă recurența FiA e posibilă și după o ablație reușită. Cel puțin 4 ore de dormit cu CPAP pe noapte ameliorează spectaculos problemele.

PS: Nu vreau să te descurajez, dar evoluția FiA e spre cronicizare, din păcate, nicidecum spre "ținut sub control"...
Sănătate maximă și reflectează bine la ce ți-am spus! Îți vreau, ca și altora, numai binele! big hug
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08-10-2014, 08:40 PM
Mesaj: #10
RE: 15th BOSTON A-FIB SYMPOSIUM, January 14-16, 2010 "Atrial Fibrillation: Mechanisms and
La 23,45 pe digi life este o emisiune despre inima si fibrilatia atriala. Este adevarat ca ora nu prea este prea potrivita pentru cei cu probleme cardiace dar poate e ceva interesant...
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